In this episode, a new videotape in the plan demands technology that William Bell kept hidden from the team. Happy to see her old friends, Nina Sharp helps retrieve the crucial elements. Meanwhile, Peter works an independent angle against the Observers and scores a minor victory.
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Walter discusses how he trusted Bell before Bell betrayed them to gain favor with the Observers.
Observers are featured in this episode.
The bell-shaped lamp in the pocket universe in 'Through the Looking-Glass and What Walter Found There' foreshadows the team gaining access to William Bell's storage facility in 'Five-Twenty-Ten'.
The scaffolding near Kelvin Genetics in 'Five-Twenty-Ten' has "Oracle" written on it, foreshadowing Simone's oracle-like sensibilities in 'The Human Kind'.
The combination to access Bell's safe in "Five-Twenty-Ten" was 0-5-2-0-1-0, the same combination Walter used to access the daycare center.
Olivia gave Nina a hug and a kiss in "Five-Twenty-Ten", suggesting that they reformed a personal relationship.