This episode follows the attempts of Thomas Jerome Newton, with the help of shapeshifters, to create a pathway between the two parallel universes. Upon discovering a shape-shifting embryo, Walter returns to the lab to conduct further analysis, and Olivia and Peter head to Massive Dynamic for answers. Meanwhile, Peter reveals a family secret to Olivia as Walter struggles to recall what Newton knows about "building a door."
This episode's glyphs spell:
Thomas Newton succeeded in bringing a bridge from the Redverse over to the Bluverse, carrying a man over with it.
The Observer can be seen at the counter when Newton walks into the bank.
The motto of the transit system in 'White Tulip', "Be There in No Time", foreshadows the nearly instantaneous transfer between universes by 'Mr. Secretary' and the Shapeshifters in 'The Man from the Other Side'.
"For Your Healthy Heart!", written on an egg carton in 'The Man from the Other Side', foreshadows Walter's tale of a broken heart in 'Brown Betty'.
In "The Boy Must Live" Walter told Peter that he remembered the first time Peter called him "Dad" in "The Man from the Other Side".